Intramolecular single-turnover reaction in a cytochrome c oxidase model bearing a Tyr244 mimic

被引：48

作者：

Collman, James P. ^{[1
]}

Decreau, Richard A. ^{[1
]}

Yan, Yilong ^{[1
]}

Yoon, Jungjoo ^{[1
]}

Solomon, Edward I. ^{[1
]}

机构：

[1] Stanford Univ, Dept Chem, Stanford, CA 94305 USA

来源：

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY | 2007年 / 129卷 / 18期

关键词：

D O I：

10.1021/ja0690969

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

A close structural analogue of the cytochrome c oxidase active site has been synthesized. Oxygenation at -60 degrees C leads to a stable Fe(III)-superoxide-Cu(I) intermediate oxy-1 which reacts intramolecularly at -40 degrees C and faithfully reproduces the single turnover reaction that occurs in the enzyme leading to the formation of an oxoferryl-cupric-phenoxyl radical species 2.

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收藏

页码：5794 / +

页数：3

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