The DOSY experiment provides insights into the protegrin-lipid interaction

被引:8
作者
Malliavin, TE [1 ]
Louis, V [1 ]
Delsuc, MA [1 ]
机构
[1] Fac Pharm Montpellier, INSERM, CNRS, Ctr Biochim Struct,UMR 9955,U414, F-34000 Montpellier, France
关键词
DOSY; micelle; protegrin; MaxEnt;
D O I
10.1051/jcp:1998118
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
The measure of translational diffusion using PFG NMR has known a renewal of interest with the development of the DOSY experiments. The extraction of diffusion coefficients from these experiments requires an inverse Laplace transform. We present here the use of the Maximum Entropy technique to perform this transform, and an application of this method to investigate the interaction protegrin-lipid. We show that the analysis by DOSY experiments permits to determine some of the interaction features.
引用
收藏
页码:178 / 186
页数:9
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