The neurotrophin NT4/5, but not NT3, enhances the efficacy of nigral grafts in a rat model of Parkinson's disease

被引：55

作者：

Haque, NSK

Hlavin, ML

Fawcett, JW

Dunnett, SB

机构：

[1] UNIV CAMBRIDGE, MRC, CAMBRIDGE CTR BRAIN REPAIR, CAMBRIDGE CB2 2PY, ENGLAND

[2] UNIV CAMBRIDGE, DEPT EXPTL PATHOL, CAMBRIDGE CB2 2PY, ENGLAND

[3] UNIV CAMBRIDGE, DEPT PHYSIOL, CAMBRIDGE CB2 2PY, ENGLAND

来源：

BRAIN RESEARCH | 1996年 / 712卷 / 01期

关键词：

neurotrophin; Parkinson's disease; nigral graft; fibre outgrowth;

D O I：

10.1016/0006-8993(95)01427-6

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

The neurotrophins NT4/5 and NT3 have previously been shown to improve the survival and fibre outgrowth of embryonic dopaminergic neurons in vitro. In the present study we attempted to augment the efficacy of embryonic nigral grafts in vivo. This was done by directly infusing the neurotrophins intraparenchymally in close proximity to transplanted nigral tissue placed in the dopamine depleted striatum of 6-hydroxydopamine lesioned rats. Our results indicated that NT4/5, but not NT3, stimulated fibre growth from embryonic nigral cells and enhanced functional efficacy of the grafts as assessed by metamphetamine-induced rotation.

引用

页码：45 / 52

页数：8

共 27 条

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