Longitudinal analysis of nef/long terminal repeat-deleted HIV-1 in blood and cerebrospinal fluid of a long-term survivor who developed HIV-associated dementia

被引：25

作者：

Churchill, M

Sterjovski, J

Gray, L

Cowley, D

Chatfield, C

Learmont, J

Sullivan, JS

Crowe, SM

Mills, J

Brew, BJ

Wesselingh, SL

McPhee, DA

Gorry, PR

机构：

[1] Macfarlane Burnet Inst Med Res & Publ Hlth, Melbourne, Vic 3001, Australia

[2] Monash Univ, Dept Med, Melbourne, Vic 3004, Australia

[3] Univ Melbourne, Dept Microbiol & Immunol, Parkville, Vic 3052, Australia

[4] Univ Sydney, Australian Red Cross Blood Serv, Sydney, NSW, Australia

[5] Univ Sydney, Fac Med, Sydney, NSW, Australia

[6] St Vincents Hosp, Darlinghurst, NSW 2010, Australia

来源：

JOURNAL OF INFECTIOUS DISEASES | 2004年 / 190卷 / 12期

基金：

英国医学研究理事会; 美国国家卫生研究院;

关键词：

D O I：

10.1086/425585

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

We studied the evolution and compartmentalization of nef/ long terminal repeat ( nef/ LTR) - deleted human immunodeficiency virus type 1 (HIV-1) from a long-term survivor who developed HIV-associated dementia (HIVD). Analysis of sequential blood-derived HIV-1 isolated before and during HIVD revealed a persistent R5X4 phenotype and a progressive loss of nef/ LTR sequence; in contrast, HIV-1 present in cerebrospinal fluid during HIVD had an R5 phenotype, distinct nef/ LTR sequence of unique deletions and additional nuclear factor - kappaB sites and specificity factor - 1 sites, and enhanced transcriptional activity, compared with the blood-derived isolates. Thus, nef/LTR-deleted HIV-1 strains may undergo compartmentalized evolution in long-term survivors and cause neurologic disease.

引用

收藏

页码：2181 / 2186

页数：6

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