Convenient synthesis and isolation of 1-aminocyclopropane-1-carboxylic acid (ACC) and N-protected ACC derivatives

被引：11

作者：

Allwein, SP

Secord, EA

Martins, A

Mitten, JV

Nelson, TD

Kress, ML

Dolling, UH

机构：

[1] Merck Res Labs, Dept Proc Res, Wayne, PA 19087 USA

[2] Merck Res Labs, Dept Proc Res, Rahway, NJ 07065 USA

来源：

SYNLETT | 2004年 / 14期

关键词：

amino acids; imine alkylation; intramolecular alkylation; hydrogenation;

D O I：

10.1055/s-2004-834793

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A convenient route to 1-aminocyclopropane-1-carboxylic acid (1. ACC) and N-protected derivatives was developed. This route utilizes a bisalkylation of an O-benzyl glycine derived imine followed by global deprotection via hydrogenation. Direct isolation of ACC from a non-aqueous stream or efficient conversion to N-protected derivatives in a single flask is described.

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收藏

页码：2489 / 2492

页数：4

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