Persisting low use of antipsychotics in the treatment of major depressive disorder with psychotic features

被引:35
作者
Andreescu, Carmen
Mulsant, Benoit H.
Peasley-Miklus, Catherine
Rothschild, Anthony J.
Flint, Alastair J.
Heo, Moonseong
Caswell, Melynda
Whyte, Ellen M.
Meyers, Barnett S.
机构
[1] Univ Pittsburgh, Sch Med, Western Psychiat Inst & Clin, Dept Psychiat, Pittsburgh, PA USA
[2] Univ Toronto, Dept Psychiat, Ctr Addict & Mental Hlth, Toronto, ON, Canada
[3] Univ Hlth Network, Toronto Gen Res Inst, Toronto, ON, Canada
[4] Toronto Rehabil Inst, Geriatr Program & Res Inst, Toronto, ON, Canada
[5] Univ Massachusetts, Sch Med, Dept Psychiat, Worcester, MA 01655 USA
[6] UMass Mem Hlth Care, Worcester, MA USA
[7] Cornell Univ, Weill Med Coll, Dept Psychiat, New York, NY USA
[8] New York Presbyterian Hosp Westchester, White Plains, NY USA
关键词
D O I
10.4088/JCP.v68n0203
中图分类号
B849 [应用心理学];
学科分类号
040203 ;
摘要
Objective: Practice guidelines recommend the use of a combination of an antidepressant and an antipsychotic for the pharmacologic treatment of major depressive disorder with psychotic features (MD-Psy). We assessed the extent to which the pharmacotherapy received by patients with MD-Psy under usual care conforms to these recommendations. Method: We assessed the pharmacotherapy received under usual care conditions by 100 patients with MD-Psy prior to enrollment in STOP-PD (Study of the Pharmacotherapy of Psychotic Depression), a 12-week randomized, controlled trial comparing olanzapine plus sertraline to olanzapine plus placebo. Our assessment took place from January 2003 to May 2004. The strength of antidepressant trials was rated using the Antidepressant Treatment History Form (ATHF). The strength of antipsychotic trials or combinations of antidepressants and antipsychotics was rated using a modified version of the ATHF. We also determined whether the strength of antipsychotic or combination trials was associated with age, the duration of the current depressive episode, medical burden, cognitive status, or the severity of depressive or psychotic symptoms. Results: Most patients with MD-Psy were treated with antidepressants (N = 82, 82%) or antipsychotics (N = 65, 65%). About half of the patients (N = 48, 48%) received therapeutic doses of an antidepressant; 10% (N = 10) received an intermediate dose of an antipsychotic, and 6% (N = 6) received a high dose. Overall, only 5% (N = 5) received a combination of an adequate dose of an antidepressant and a high dose of an antipsychotic. The strength of both antipsychotic trials (p =.021) and combination trials (p =.039) was significantly associated only with a longer duration of the current depressive episode. Conclusions: These findings show a persisting low use of antipsychotics in the treatment of MD-Psy. Given the high morbidity rates associated with MD-Psy, it is important to continue to educate clinicians regarding its identification and treatment.
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收藏
页码:194 / 200
页数:7
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