Porous nanocomposites of PEG-PLA/calcium phosphate: room-temperature synthesis and its application in drug delivery

被引：37

作者：

Tang, Qi-Li ^{[1
,2
]}

Zhu, Ying-Jie ^{[1
,2
]}

Duan, You-Rong ^{[3
]}

Wang, Qi

Wang, Ke-Wei ^{[1
]}

Cao, Shao-Wen ^{[1
]}

Chen, Feng ^{[1
,2
]}

Wu, Jin ^{[1
,2
]}

机构：

[1] Chinese Acad Sci, State Key Lab High Performance Ceram & Superfine, Shanghai Inst Ceram, Shanghai 200050, Peoples R China

[2] Chinese Acad Sci, Grad Sch, Shanghai 200050, Peoples R China

[3] Shanghai Canc Inst, Shanghai 200032, Peoples R China

来源：

DALTON TRANSACTIONS | 2010年 / 39卷 / 18期

基金：

中国国家自然科学基金;

关键词：

AMORPHOUS CALCIUM-PHOSPHATE; POLY(ETHYLENE GLYCOL); IN-VITRO; MICELLES; NANOPARTICLES; COPOLYMERS; HYDROXYAPATITE; MINERALIZATION; SILICATE; BEHAVIOR;

D O I：

10.1039/b925779a

中图分类号：

O61 [无机化学];

学科分类号：

070301 ; 081704 ;

摘要：

We report room-temperature preparation of poly(ethylene glycol)-block-polylactide (PEG-PLA)/calcium phosphate (CP) nanocomposites with a porous morphology. The reaction time and concentration of the inorganic ingredients play an important role in the morphology and chemical composition of the nanocomposite. Thermogravimetry analysis shows that there is approximately 8.5 wt.% of PEG-PLA block copolymer in the nanocomposite. A typical anti-inflammatory drug, ibuprofen, is used to evaluate the drug loading ability and the release behavior of the porous PEG-PLA/CP nanocomposite. The experiments reveal that the nanocomposite has a higher drug loading capacity and favorable drug release property. The drug release kinetics of the porous PEG-PLA/CP nanocomposite is discussed as a three-stage process. The as-prepared porous PEG-PLA/CP nanocomposite is promising for application in drug delivery.

引用

页码：4435 / 4439

页数：5

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