Molecular interactions of coreceptor CD8 and MHC class I: the molecular basis for functional coordination with the T-cell receptor

被引：130

作者：

Gao, GF

Jakobsen, BK

机构：

[1] Childrens Hosp, Mol Med Lab, Boston, MA 02115 USA

[2] Univ Oxford, Inst Mol Med, Nuffield Dept Clin Med, Oxford OX3 9DS, England

来源：

IMMUNOLOGY TODAY | 2000年 / 21卷 / 12期

关键词：

D O I：

10.1016/S0167-5699(00)01750-3

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

In recent years, substantial progress Iras been made towards understanding the molecular basis for CDS binding to class I MHC and the coreceptor's role in cytotoxic T-cell activation, Here, we review th structural, mechanistic and functional studies that point to a model of coordination of T-cell receptor and CDS signaling that might provide the key to cytotoxic T-cell activation.

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收藏

页码：630 / 636

页数：7

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