Regulation of receptors and transporters by ubiquitination: New insights into surprisingly similar mechanisms

被引：168

作者：

Miranda, Manuel ^{[1
]}

Sorkin, Alexander ^{[1
]}

机构：

[1] Univ Colorado, Ctr Hlth Sci, Dept Pharmacol, Aurora, CO 80045 USA

来源：

MOLECULAR INTERVENTIONS | 2007年 / 7卷 / 03期

关键词：

D O I：

10.1124/mi.7.3.7

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The function of many receptors and transport proteins that reside at the surface of the cell is regulated by endocytosis and post-endocytic trafficking. Modification of receptors and transporters by ubiquitin conjugation has recently emerged as the major regulatory mechanism of internalization and intracellular sorting of these membrane proteins. This review will describe recent advances in elucidating the mechanisms of ubiquitination of mammalian receptors and transporters using two examples: the receptor for epidermal growth factor and the dopamine transporter. How ubiquitination controls the endocytosis and turnover of these proteins will be also discussed.

引用

页码：157 / 167

页数：11

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