Polyamide struts for DNA architectures

被引：33

作者：

Schmidt, Thorsten L.

Nandi, Chayan K.

Rasched, Goran

Parui, Partha P.

Brutschy, Bernd

Famulok, Michael

Heckel, Alexander

机构：

[1] Univ Frankfurt, Inst Phys & Theoret Chem, D-60439 Frankfurt, Germany

[2] Univ Bonn, LIMES Life & Med Sci, D-53121 Bonn, Germany

来源：

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2007年 / 46卷 / 23期

关键词：

dervan polyamides; DNA recognition; nanostructures;

D O I：

10.1002/anie.200700469

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Copy and paste: A DNA strut consisting of two Dervan polyamides is constructed with two sides that can sequence-selectively bind double-stranded DNA. This strut can be used as sequence-selective glue for DNA architectures and can easily combine DNA objects that are 100 times its mass. (Figure Presented). © 2007 Wiley-VCH Verlag GmbH & Co. KGaA.

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页码：4382 / 4384

页数：3

相关论文

共 23 条

[1] DNA:: A programmable force sensor [J].

Albrecht, C ;

Blank, K ;

Lalic-Mülthaler, M ;

Hirler, S ;

Mai, T ;

Gilbert, I ;

Schiffmann, S ;

Bayer, T ;

Clausen-Schaumann, H ;

Gaub, HE .

SCIENCE, 2003, 301 (5631) :367-370

[2] Regulation of gene expression by synthetic DNA-binding ligands [J].

Dervan, PB ;

Poulin-Kerstien, AT ;

Fechter, EJ ;

Edelson, BS .

DNA BINDERS AND RELATED SUBJECTS, 2005, 253 :1-31

[3] Molecular recognition of DNA by small molecules [J].

Dervan, PB .

BIOORGANIC & MEDICINAL CHEMISTRY, 2001, 9 (09) :2215-2235

[4] Nucleosomes in solution exist as a mixture of twist-defect states [J].

Edayathumangalam, RS ;

Weyermann, P ;

Dervan, PB ;

Gottesfeld, JM ;

Luger, K .

JOURNAL OF MOLECULAR BIOLOGY, 2005, 345 (01) :103-114

[5] Molecular recognition of the nucleosomal "supergroove" [J].

Edayathumangalam, RS ;

Weyermann, P ;

Gottesfeld, JM ;

Dervan, PB ;

Luger, K .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2004, 101 (18) :6864-6869

[6] Rational design of DNA nanoarchitectures [J].

Feldkamp, U ;

Niemeyer, CM .

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, 2006, 45 (12) :1856-1876

[7]

Feldkamp U., 2006, Angew. Chem, V118, P1888, DOI [10.1002/ange.200502358, DOI 10.1002/ANGE.200502358]

[8] DNA DOUBLE-CROSSOVER MOLECULES [J].

FU, TJ ;

SEEMAN, NC .

BIOCHEMISTRY, 1993, 32 (13) :3211-3220

[9] Rapid assay processing by integration of dual-color fluorescence cross-correlation spectroscopy: High throughput screening for enzyme activity [J].

Koltermann, A ;

Kettling, U ;

Bieschke, J ;

Winkler, T ;

Eigen, M .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1998, 95 (04) :1421-1426

[10] DNA nanotubes self-assembled from triple-crossover tiles as templates for conductive nanowires [J].

Liu, D ;

Park, SH ;

Reif, JH ;

LaBean, TH .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2004, 101 (03) :717-722