Small molecule Mcl-1 inhibitors for the treatment of cancer

被引：145

作者：

Belmar, Johannes ^{[1
]}

Fesik, Stephen W. ^{[1
]}

机构：

[1] Vanderbilt Univ, Sch Med, Dept Biochem, Nashville, TN 37232 USA

来源：

PHARMACOLOGY & THERAPEUTICS | 2015年 / 145卷

关键词：

Mcl-1; Myeloid cell leukemia-1; Inhibitors; Small molecule; BH3-mimetic; CELL LUNG-CANCER; BCL-2 FAMILY PROTEINS; ANTI-APOPTOTIC MCL-1; BH3 MIMETIC ABT-737; TARGETING MCL-1; MELANOMA-CELLS; IMMUNOHISTOCHEMICAL ANALYSIS; BIOLOGICAL EVALUATION; RATIONAL DESIGN; RESISTANCE;

D O I：

10.1016/j.pharmthera.2014.08.003

中图分类号：

R9 [药学];

学科分类号：

100702 [药剂学];

摘要：

The Bcl-2 family of proteins serves as primary regulators of apoptosis. Myeloid cell leukemia 1 (Mcl-1), a prosurvival member of the Bcl-2 family of proteins, is overexpressed and the Mcl-1 gene is amplified in many tumor types. Moreover, the overexpression of Mcl-1 is the cause of resistance to several chemotherapeutic agents. Thus, Mcl-1 is a promising cancer target. This review highlights the current progress on the discovery of small molecule Mcl-1 inhibitors. (C) 2014 Elsevier Inc. All rights reserved.

引用

收藏

页码：76 / 84

页数：9

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