A type IV pilin, PilA, contributes to adherence of Burkholderia pseudomallei and virulence in vivo

被引：82

作者：

Essex-Lopresti, AE ^{[1
]}

Boddey, JA

Thomas, R

Smith, MP

Hartley, MG

Atkins, T

Brown, NF

Tsang, CH

Peak, IRA

Hill, J

Beacham, IR

Titball, RW

机构：

[1] Dstl Porton Down, Salisbury SP4 0JQ, Wilts, England

[2] Griffith Univ, Inst Glycom, Gold Coast, Qld, Australia

来源：

INFECTION AND IMMUNITY | 2005年 / 73卷 / 02期

关键词：

D O I：

10.1128/IAI.73.2.1260-1264.2005

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

The Burkholderia pseudomallei K96243 genome contains multiple type IV pilin-associated loci, including one encoding a putative pilus structural protein (pilA). A pilA deletion mutant has reduced adherence to human epithelial cells and is less virulent in the nematode model of virulence and the murine model of melioidosis, suggesting a role for type IV pili in B. pseudomallei virulence.

引用

页码：1260 / 1264

页数：5

共 43 条

[1] Characterisation of an acapsular mutant of Burkholderia pseudomallei identified by signature tagged mutagenesis [J].

Atkins, T ;

Prior, R ;

Mack, K ;

Russell, P ;

Nelson, M ;

Prior, J ;

Ellis, J ;

Oyston, PCF ;

Dougan, G ;

Titball, RW .

JOURNAL OF MEDICAL MICROBIOLOGY, 2002, 51 (07) :539-547

[2] ALLELIC EXCHANGE IN ESCHERICHIA-COLI USING THE BACILLUS-SUBTILIS SACB GENE AND A TEMPERATURE-SENSITIVE PSC101 REPLICON [J].

BLOMFIELD, IC ;

VAUGHN, V ;

REST, RF ;

EISENSTEIN, BI .

MOLECULAR MICROBIOLOGY, 1991, 5 (06) :1447-1457

[3]

BRENNER S, 1974, GENETICS, V77, P71

[4] Cloning and analysis of genomic differences unique to Burkholderia pseudomallei by comparison with B-thailandensis [J].

Brown, NF ;

Beacham, IR .

JOURNAL OF MEDICAL MICROBIOLOGY, 2000, 49 (11) :993-1001

[5] Adherence of Burkholderia pseudomallei cells to cultured human epithelial cell lines is regulated by growth temperature [J].

Brown, NF ;

Boddey, JA ;

Flegg, CP ;

Beacham, IR .

INFECTION AND IMMUNITY, 2002, 70 (02) :974-980

[6] Recent advances in the treatment of severe melioidosis [J].

Chaowagul, W .

ACTA TROPICA, 2000, 74 (2-3) :133-137

[7] Flagella are virulence determinants of Burkholderia pseudomallei [J].

Chua, KL ;

Chan, YY ;

Gan, YH .

INFECTION AND IMMUNITY, 2003, 71 (04) :1622-1629

[8] Yersinia pseudotuberculosis harbors a type IV pilus gene cluster that contributes to pathogenicity [J].

Collyn, F ;

Léty, MA ;

Nair, S ;

Escuyer, V ;

Ben Younes, A ;

Simonet, M ;

Marceau, M .

INFECTION AND IMMUNITY, 2002, 70 (11) :6196-6205

[9] Melioidosis as an emerging global problem [J].

Dance, DAB .

ACTA TROPICA, 2000, 74 (2-3) :115-119

[10] Molecular genetic analysis of type-4 pilus biogenesis and twitching motility using Pseudomonas aeruginosa as a model system - A review [J].

Darzins, A ;

Russell, MA .

GENE, 1997, 192 (01) :109-115

← 1 2 3 4 5 →