Cell division orientation and planar cell polarity pathways

被引:74
作者
Segalen, Marion [1 ]
Bellaiche, Yohanns [1 ]
机构
[1] Inst Curie, Equipe Polarite, Div & Morphogenese, U934,UMR3215, F-75248 Paris 05, France
关键词
Planar cell polarity; Mitotic spindle; Asymmetric cell division; Morphogenesis; HETEROTRIMERIC G-PROTEINS; G-ALPHA-I; NEUROBLAST ASYMMETRIC DIVISIONS; CAENORHABDITIS-ELEGANS EMBRYOS; REGULATES SPINDLE ORIENTATION; MITOTIC SPINDLE; C.-ELEGANS; DROSOPHILA NEUROBLASTS; MEMBRANE LOCALIZATION; TUMOR-SUPPRESSOR;
D O I
10.1016/j.semcdb.2009.03.018
中图分类号
Q2 [细胞生物学];
学科分类号
071009 ; 090102 ;
摘要
The orientation of cell division has a crucial role in early embryo body plan specification, axis determination and cell fate diversity generation, as well as in the morphogenesis of tissues and organs. In many instances, cell division orientation is regulated by the planar cell polarity (PCP) pathways: the Wnt/Frizzled non-canonical pathway or the Fat/Dachsous/Four-jointed pathway. Firstly, using asymmetric cell division in both Drosophila and C. elegans, we describe the central role of the Wnt/Frizzled pathway in the regulation of asymmetric cell division orientation, focusing on its cooperation with either the Src kinase pathway or the heterotrimeric G protein pathway. Secondly, we describe our present understanding of the mechanisms by which the planar cell polarity pathways drive tissue morphogenesis by regulating the orientation of symmetric cell division within a field of cells. Finally, we will discuss the important avenues that need to be explored in the future to better understand how planar cell polarity pathways control embryo body plan determination, cell fate specification or tissue morphogenesis by mitotic spindle orientation. (C) 2009 Elsevier Ltd. All rights reserved.
引用
收藏
页码:972 / 977
页数:6
相关论文
共 62 条
  • [11] Drosophila Ric-8 regulates Gαi cortical localization to promote Gαi-dependent planar orientation of the mitotic spindle during asymmetric cell division
    David, NB
    Martin, CA
    Segalen, M
    Rosenfeld, F
    Schweisguth, F
    Bellaïche, Y
    [J]. NATURE CELL BIOLOGY, 2005, 7 (11) : 1083 - 1090
  • [12] Davies J., 2005, MECH MORPHOGENESIS
  • [13] Trimeric G protein-dependent signaling by Frizzled receptors in animal development
    Egger-Adam, Diane
    Katanaev, Vladimir L.
    [J]. FRONTIERS IN BIOSCIENCE-LANDMARK, 2008, 13 : 4740 - 4755
  • [14] The influence of cell mechanics, cell-cell interactions, and proliferation on epithelial packing
    Farhadifar, Reza
    Roeper, Jens-Christian
    Algouy, Benoit
    Eaton, Suzanne
    Juelicher, Frank
    [J]. CURRENT BIOLOGY, 2007, 17 (24) : 2095 - 2104
  • [15] Defective planar cell polarity in polycystic kidney disease
    Fischer, E
    Legue, E
    Doyen, A
    Nato, F
    Nicolas, JF
    Torres, V
    Yaniv, M
    Pontoglio, M
    [J]. NATURE GENETICS, 2006, 38 (01) : 21 - 23
  • [16] Porcupine-mediated lipid-modification regulates the activity and distribution of Wnt proteins in the chick neural tube
    Galli, Lisa M.
    Barnes, Tiffany L.
    Secrest, Stephanie S.
    Kadowaki, Tatsuhiko
    Burrus, Laura W.
    [J]. DEVELOPMENT, 2007, 134 (18): : 3339 - 3348
  • [17] Frizzled signalling controls orientation of asymmetric sense organ precursor cell divisions in Drosophila
    Gho, M
    Schweisguth, F
    [J]. NATURE, 1998, 393 (6681) : 178 - 181
  • [18] The emergence of geometric order in proliferating metazoan epithelia
    Gibson, Matthew C.
    Patel, Ankit B.
    Nagpal, Radhika
    Perrimon, Norbert
    [J]. NATURE, 2006, 442 (7106) : 1038 - 1041
  • [19] Mechanisms of asymmetric cell division:: flies and worms pave the way
    Goenczy, Pierre
    [J]. NATURE REVIEWS MOLECULAR CELL BIOLOGY, 2008, 9 (05) : 355 - 366
  • [20] CELL CONTACTS ORIENT SOME CELL-DIVISION AXES IN THE CAENORHABDITIS-ELEGANS EMBRYO
    GOLDSTEIN, B
    [J]. JOURNAL OF CELL BIOLOGY, 1995, 129 (04) : 1071 - 1080