A multigene RT-PCR assay used to predict recurrence in early breast cancer: two presentations with contradictory results

被引：2

作者：

Fiets, WE ^{[1
]}

Nortier, JWR ^{[1
]}

机构：

[1] Leiden Univ, Med Ctr, Dept Med Oncol, NL-2300 RA Leiden, Netherlands

来源：

BREAST CANCER RESEARCH | 2004年 / 6卷 / 05期

关键词：

breast cancer; predictive marker; prognostic marker; RNA;

D O I：

10.1186/bcr911

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

During the 2003 San Antonio Breast Cancer Symposium two studies were presented that were designed to validate a recurrence score, derived from a 21-gene RT-PCR assay, in patients with axillary node-negative breast cancer. This recurrence score was highly predictive for the risk of recurrence in 668 patients treated in a large multicenter trial with adjuvant tamoxifen. However, no prognostic value was found in a small group of patients who were retrospectively selected in a single institution and who did not receive any adjuvant systemic therapy. Further validation is needed to establish the prognostic and predictive role of this assay in clinical management.

引用

页码：185 / 187

页数：3

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