Plasmon resonant particles for biological detection

被引：304

作者：

Schultz, DA ^{[1
]}

机构：

[1] Univ Calif San Diego, Dept Phys, La Jolla, CA 92093 USA

来源：

CURRENT OPINION IN BIOTECHNOLOGY | 2003年 / 14卷 / 01期

基金：

美国国家科学基金会;

关键词：

SCATTERING SUBMICROSCOPIC PARTICLES; HIGHLY FLUORESCENT ANALOGS; GOLD NANOPARTICLES; DNA HYBRIDIZATION; OLIGONUCLEOTIDE ARRAYS; COLORIMETRIC DETECTION; OPTICAL-PROPERTIES; TRACER LABELS; SINGLE; LIGHT;

D O I：

10.1016/S0958-1669(02)00015-0

中图分类号：

Q5 [生物化学];

学科分类号：

071010 ; 081704 ;

摘要：

Several recent advances in the optical observation, fabrication, and bioconjugation of nanometer-sized gold or silver colloids have produced a robust new class of label. These plasmon resonant particle (PRP) conjugates have several important advantages: they are ultra-bright, so the light scattered from the individual particles can be viewed using a simple optical microscope system with a white light illumination source; they do not photo-bleach; PRPs can be prepared that preferentially scatter light of a chosen color; and it is possible to prepare bioconjugated PRPs that are stable in solution. These properties, and the automation of PRIP identification, discrimination, and counting, have enabled the development of ultrasensitive, multicolor, and multiplex applications in the life science field.

引用

页码：13 / 22

页数：10

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