Design and synthesis of heterocyclic carboxamides as natural nucleic acid base mimics

被引：24

作者：

Bergstrom, DE ^{[1
]}

Zhang, PM ^{[1
]}

Johnson, WT ^{[1
]}

机构：

[1] PURDUE UNIV,DEPT MED CHEM & PHARMACOGNOSY,W LAFAYETTE,IN 47907

来源：

NUCLEOSIDES & NUCLEOTIDES | 1996年 / 15卷 / 1-3期

关键词：

D O I：

10.1080/07328319608002370

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

A series of heterocyclic carboxamides have been designed as mimics for the natural nucleic acid bases. The nucleosides 1-(2'-deoxy-beta-D-ribofuranosyl)imidazole-4-carboxamide (1), 1-(2'-deoxy-beta-D-ribofuranosyl)pyrazole-3-carboxamide (2), and 1-(2'-deoxy-beta-D-ribofuranosy])pyrrole-3-carboxamide (3) were synthesized and their structures confirmed by spectroscopic and analytical means.

引用

页码：59 / 68

页数：10

共 20 条

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