Heme oxygenase 1 expression in rat liver during ageing and ethanol intoxication

被引：28

作者：

Patriarca, Stefania ^{[1
]}

Furfaro, Anna Lisa ^{[1
]}

Cosso, Luana ^{[1
]}

Maineri, Elena Pesce ^{[1
]}

Balbis, Emanuela ^{[1
]}

Domenicotti, Cinzia ^{[1
]}

Nitti, Mariapaola ^{[1
]}

Cottalasso, Damiano ^{[1
]}

Marinari, Umberto Maria ^{[1
]}

Pronzato, Maria Adelaide ^{[1
]}

Traverso, Nicola ^{[1
]}

机构：

[1] Univ Genoa, Sect Gen Pathol, Dept Expt Med, I-16132 Genoa, Italy

来源：

BIOGERONTOLOGY | 2007年 / 8卷 / 03期

关键词：

heme oxygenase 1; development; ageing; ethanol; liver; lipid peroxidation;

D O I：

10.1007/s10522-006-9079-x

中图分类号：

R592 [老年病学]; C [社会科学总论];

学科分类号：

03 ; 0303 ; 100203 ;

摘要：

Heme oxygenase 1 (HO-1) expression is recognized as a marker of cellular response to oxidative stress; since ageing is believed to be related to oxidative "wear and tear", HO-1 may represent a candidate biomarker of ageing. In our study, the hepatic expression of HO-1 mRNA, evaluated by RT-PCR in 2.5-24 month-old rats, was higher at 6 months than at 2.5 months of age, but thereafter increased no further: on the contrary, a declining trend was observed. However, while 2.5 month-old rats responded to acute ethanol intoxication by displaying increased expression of liver HO-1 mRNA, and 6 month-old rats exhibited a mild response, 18 month-old rats did not show any response; this phenomenon suggests that during development and ageing the transcriptional response to oxidative stress decreases. In our view, the finding that HO-1 expression did not increase progressively during ageing may be explained by a decreased transcriptional ability to respond to stress in older animals, rather than by a reduction in oxidative stress.

引用

页码：365 / 372

页数：8

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