ODNBase - a web database for antisense oligonucleotide effectiveness studies

被引:19
作者
Giddings, MC [1 ]
Matveeva, OV [1 ]
Atkins, JF [1 ]
Gesteland, RF [1 ]
机构
[1] Univ Utah, Dept Human Genet, SLC, Salt Lake City, UT 84112 USA
关键词
D O I
10.1093/bioinformatics/16.9.843
中图分类号
Q5 [生物化学];
学科分类号
071010 ; 081704 ;
摘要
ODNBase is a database of antisense oligodeoxynucleotides targeted to mammalian mRNAs that were reported in the literature. It includes the oligo sequences tested, the measured effectiveness, the RNA that was targeted, the type of measurement assay used, the oligo concentration applied, and the reference for each oligo. It provides a searchable interface by motif content, activity level, applied concentration and RNA name. Oligo lists matching search criteria can be downloaded in a spreadsheet compatible format.
引用
收藏
页码:843 / 844
页数:2
相关论文
共 6 条
[1]   A good antisense molecule is hard to find [J].
Branch, AD .
TRENDS IN BIOCHEMICAL SCIENCES, 1998, 23 (02) :45-50
[2]   Synthetic oligonucleotides: Useful molecules? A review [J].
Calogero, A ;
Hospers, GAP ;
Mulder, NH .
PHARMACY WORLD & SCIENCE, 1997, 19 (06) :264-268
[3]   A theoretical approach to select effective antisense oligodeoxyribonucleotides at high statistical probability [J].
Patzel, V ;
Steidl, U ;
Kronenwett, R ;
Haas, R ;
Sczakiel, G .
NUCLEIC ACIDS RESEARCH, 1999, 27 (22) :4328-4334
[4]   Keeping the biotechnology of antisense in context [J].
Stein, CA .
NATURE BIOTECHNOLOGY, 1999, 17 (03) :209-209
[5]   Tetranucleotide GGGA motif in primary RNA transcripts - Novel target site for antisense design [J].
Tu, GC ;
Cao, QN ;
Zhou, F ;
Israel, Y .
JOURNAL OF BIOLOGICAL CHEMISTRY, 1998, 273 (39) :25125-25131
[6]   ON FINDING ALL SUBOPTIMAL FOLDINGS OF AN RNA MOLECULE [J].
ZUKER, M .
SCIENCE, 1989, 244 (4900) :48-52