Risk to Nonparticipants in HIV Remission Studies With Treatment Interruption: A Symposium

被引：18

作者：

Eyal, Nir ^{[1
]}

Deeks, Steven G. ^{[2
]}

机构：

[1] Rutgers State Univ, Ctr Populat Level Bioeth, 112 Paterson St, New Brunswick, NJ 08901 USA

[2] Univ Calif San Francisco, Dept Med, San Francisco, CA USA

来源：

JOURNAL OF INFECTIOUS DISEASES | 2019年 / 220卷

关键词：

HIV; research ethics; analytic treatment interruption; HIV cure-related studies; immunotherapy; pre-exposure prophylaxis; ETHICS; WOMEN;

D O I：

10.1093/infdis/jiz173

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Ethical guidelines and recommendations for human subjects research typically focus on protecting the individuals who directly participate in that research. However, additional people, including sex partners of research participants, can also face harms and burdens from medical studies. In human immunodeficiency virus (HIV) cure-related research, a persistent ethical and practical challenge surrounds the use of analytical antiretroviral treatment interruptions. The challenge is usually discussed in relation to risks to study participants, but serious dangers accrue to nonparticipants, including sex partners of study participants. This multidisciplinary supplement relays the risks for nonparticipating sex partners in HIV cure-related studies and addresses the ethical dilemmas raised by these studies, with recommendations for researchers, advocates, sponsors, and oversight bodies.

引用

页码：S1 / S4

页数：4

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