Real-time fMRI of cortico-limbic brain activity during emotional processing

被引：33

作者：

Phan, KL ^{[1
]}

Fitzgerald, DA ^{[1
]}

Gao, KX ^{[1
]}

Moore, GJ ^{[1
]}

Tancer, ME ^{[1
]}

Posse, S ^{[1
]}

机构：

[1] Wayne State Univ, Sch Med, Dept Psychiat & Behav Neurosci, Brain Imaging Res Div, Detroit, MI 48201 USA

来源：

NEUROREPORT | 2004年 / 15卷 / 03期

关键词：

affect; amygdala; anterior cingulate cortex; brain imaging; cortico-limbic; emotion; fMRI; insula; medial prefrontal cortex; real-time;

D O I：

10.1097/00001756-200403010-00029

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

The ability to detect dynamic changes in brain activity during affective processing within individual subjects in real-time can advance our understanding of the neural mechanisms of emotion, psychiatric illness, and therapeutic intervention. We investigated whether activity in limbic and paralimbic regions elicited by blocks of aversive (AV) and neutral (NEU) pictures can be detected by real-time fMRI. Real-time analysis of signal change during each block revealed that activations in insula and medial frontal cortex were more frequent during AV than NEU epochs. Single subject and group analysis off-line with conventional statistical parametric mapping methods matched the results obtained in real-time. Detecting cortico-limbic brain activation during perception and experience of emotionally salient visual stimuli with real-time fMRI technology is feasible.

引用

页码：527 / 532

页数：6

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