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Low frequency of the disease-associated DRB1*15-DQB1*06 haplotype may contribute to the low prevalence of multiple sclerosis in Sami

被引：29
作者：
Harbo, H. F. [1 ]
Utsi, E.
Lorentzen, A. R.
Kampman, M. T.
Celius, E. G.
Myhr, K. -M.
Lie, B. A.
Mellgren, S. I.
Thorsby, E.
机构：
[1] Univ Oslo, Rikshosp, Univ Hosp, Fac Div,Inst Immunol, N-0027 Oslo, Norway
[2] Ullevaal Univ Hosp, Dept Neurol, Oslo, Norway
[3] Karasjok Heart Ctr, Karasjok, Norway
[4] Univ Hosp N Norway, Dept Neurol, Tromso, Norway
[5] Univ Tromso, Inst Clin Med, Tromso, Norway
[6] Haukeland Hosp, Dept Neurol, N-5021 Bergen, Norway
[7] Univ Bergen, Neurol Sect, Dept Clin Med, Bergen, Norway
[8] Natl Hosp Norway, Norwegian Radium Hosp, Med Ctr, Inst Immunol, Oslo, Norway
来源：
TISSUE ANTIGENS | 2007年 / 69卷 / 04期
关键词：
HLA genes; genetic susceptibility; multiple sclerosis; Sami;
D O I：
10.1111/j.1399-0039.2007.00803.x
中图分类号：
Q2 [细胞生物学];
学科分类号：
071009 [细胞生物学]; 090102 [作物遗传育种];
摘要：
This study confirms a low frequency of multiple sclerosis (MS) among Sami. Only 12 Sami with a diagnosis of MS were identified in the Norwegian Sami population, which represents a significantly lower prevalence of MS in Sami (30/10(5)) compared with other Norwegians (73-164/10(5)). The clinical characteristics as well as the results of human leukocyte antigen (HLA)-DRB1 and -DQB1 typing of the Sami MS patients are reported, showing that three (27%) of the Sami MS patients carried the MS-associated HLA-DRB1*15-DQB1*06 haplotype. Interestingly, the DRB1*15-DQB1*06 haplotype had a significantly reduced frequency among Sami controls (0.086) compared with non-Sami Norwegian controls (0.163) (P-corrected = 0.015). The low frequency of the disease-associated DRB1*15-DQB1*06 haplotype in the Sami population may contribute to the low prevalence of MS in Sami, in addition to other yet unidentified genetic and environmental factors.
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页码：299 / 304
页数：6
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