Synthesis of regiospecifically substituted quinolines from anilines

被引：17

作者：

Chelucci, G

Manca, A

Pinna, GA

机构：

[1] Univ Sassari, Dipartimento Chim, I-07100 Sassari, Italy

[2] Univ Sassari, Dipartimento Farmaco Chim Tossicol, I-07100 Sassari, Italy

来源：

TETRAHEDRON LETTERS | 2005年 / 46卷 / 05期

关键词：

quinolines; nitrogen heterocycles; formylation; azannulation;

D O I：

10.1016/j.tetlet.2004.12.020

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A protocol for the Sythesis of quinolines substituted on both pyridine and benzo-fused rings is reported. The method is based on the formylation of a substituted N-(tert-butoxycarbonyl)aniline followed by direct cyclisation and aromatisation of the intermediate product obtained by condensation of the formed N-Boc o-aminobenzaldehyde with an enolisable carbonyl compound. Yields up to 88% have been obtained. (C) 2004 Published by Elsevier Ltd.

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页码：767 / 770

页数：4

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