Opinion -: Somatic hypermutation at A•T pairs:: polymerase error versus dUTP incorporation

被引：113

作者：

Neuberger, MS ^{[1
]}

Di Noia, JM ^{[1
]}

Beale, RCL ^{[1
]}

Williams, GT ^{[1
]}

Yang, ZZ ^{[1
]}

Rada, C ^{[1
]}

机构：

[1] MRC, Mol Biol Lab, Cambridge CB2 2QH, England

来源：

NATURE REVIEWS IMMUNOLOGY | 2005年 / 5卷 / 02期

关键词：

D O I：

10.1038/nri1553

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Somatic hypermutation of immunoglobulin genes occurs at both C.G pairs and A.T pairs. Mutations at C.G pairs are created by activation-induced deaminase (AID)-catalysed deamination of C residues to U residues. Mutations at A.T pairs are probably produced during patch repair of the AID-generated U.G lesion, but they occur through an unknown mechanism. Here, we compare the popular suggestion of nucleotide mispairing through polymerase error with an alternative possibility, mutation through incorporation of dUTP (or another non-canonical nucleotide).

引用

页码：171 / 178

页数：8

共 75 条

[71] AID enzyme-induced hypermutation in an actively transcribed gene in fibroblasts [J].