The interferon-inducible Staf50 gene is downregulated during T cell costimulation by CD2 and CD28

被引:29
作者
Gongora, C
Tissot, C
Cerdan, C
Mechti, N
机构
[1] INSERM, U475, F-34197 Montpellier 5, France
[2] INSERM, U119 27, F-13009 Marseille, France
关键词
D O I
10.1089/10799900050198390
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
It is well established that interferons (IFN) exert potent regulatory effects on the immune system. We have recently isolated a new IFN-induced human cDNA coding for a member of the Ring finger B-box/B30.2 subfamily that localizes to the chromosome band 11p15. We have named it Staf50. We show in this report that Staf50 is expressed in resting T cells in the absence of exogenous IFN treatment and is strongly repressed during T cell activation by anti-CD28 and anti-CD2 monoclonal antibodies (mAb) at both messenger and protein levels. In addition, we show that several members of the Ring finger B-box/B30.2 subfamily, including the 52-kDa SSA/Ro autoantigen, localize to the same chromosome band, 11p15, and are upregulated by IFN. These data led us to define a family of IFN-induced genes clustered on chromosome 11p15 that may be involved in T cell regulatory processes.
引用
收藏
页码:955 / 961
页数:7
相关论文
共 33 条
[1]  
AHN JY, 1995, FEBS LETT, V366, P37, DOI 10.1016/0014-5793(95)00492-R
[2]   Immunomodulatory properties of interferon-γ -: An update [J].
Billiau, A ;
Heremans, H ;
Vermeire, K ;
Matthys, P .
MOLECULAR MECHANISMS OF FEVER, 1998, 856 :22-32
[3]  
CERDAN C, 1995, J IMMUNOL, V154, P1007
[4]  
CERDAN C, 1992, J IMMUNOL, V149, P2255
[5]   Costimulatory regulation of T cell function [J].
Chambers, CA ;
Allison, JP .
CURRENT OPINION IN CELL BIOLOGY, 1999, 11 (02) :203-210
[6]   MOLECULAR DEFINITION AND SEQUENCE MOTIFS OF THE 52-KD COMPONENT OF HUMAN SS-A/RO AUTOANTIGEN [J].
CHAN, EKL ;
HAMEL, JC ;
BUYON, JP ;
TAN, EM .
JOURNAL OF CLINICAL INVESTIGATION, 1991, 87 (01) :68-76
[7]   MULTIPLE DEFECTS OF IMMUNE CELL-FUNCTION IN MICE WITH DISRUPTED INTERFERON-GAMMA GENES [J].
DALTON, DK ;
PITTSMEEK, S ;
KESHAV, S ;
FIGARI, IS ;
BRADLEY, A ;
STEWART, TA .
SCIENCE, 1993, 259 (5102) :1739-1742
[8]   Identification of genes differentially regulated by interferon α, β, or γ using oligonucleotide arrays [J].
Der, SD ;
Zhou, AM ;
Williams, BRG ;
Silverman, RH .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1998, 95 (26) :15623-15628
[9]   CALPAIN EXPRESSION IN LYMPHOID-CELLS - INCREASED MESSENGER-RNA AND PROTEIN-LEVELS AFTER CELL ACTIVATION [J].
DESHPANDE, RV ;
GOUST, JM ;
CHAKRABARTI, AK ;
BARBOSA, E ;
HOGAN, EL ;
BANIK, NL .
JOURNAL OF BIOLOGICAL CHEMISTRY, 1995, 270 (06) :2497-2505
[10]   INTERFERON-DEPENDENT INDUCTION OF MESSENGER-RNA FOR THE MAJOR HISTOCOMPATIBILITY ANTIGENS IN HUMAN-FIBROBLASTS AND LYMPHOBLASTOID-CELLS [J].
FELLOUS, M ;
NIR, U ;
WALLACH, D ;
MERLIN, G ;
RUBINSTEIN, M ;
REVEL, M .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA-BIOLOGICAL SCIENCES, 1982, 79 (10) :3082-3086