Epstein-Barr virus: exploiting the immune system by interfering with defective ribosomal products

被引：8

作者：

Apcher, S

Fahraeus, R

Manoury, B

机构：

[1] Inst Curie, U520, F-75005 Paris, France

[2] Hop St Louis, Inst Pharmacol, EP10334, F-75010 Paris, France

来源：

MICROBES AND INFECTION | 2004年 / 6卷 / 13期

关键词：

MHC class I antigen-presentation; Epstein-Barr virus; defective ribosomal products; translation; proteasome;

D O I：

10.1016/j.micinf.2004.08.003

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

The interaction of cytotoxic T lymphocytes with major histocompatibility complex (MHC)-peptide complexes is a critical step toward the initiation and propagation of specific immune responses against viral infection. Here we review new evidence, taking Epstein-Barr virus as an example, showing that defective ribosomal products provide an important supply of endogenous peptides for entry into the MHC class I antigen-presentation pathway. (C) 2004 Elsevier SAS. All rights reserved.

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收藏

页码：1212 / 1218

页数：7

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