An insight into the mechanism and molecular basis of dysfunctional immune response involved in cholestasis

被引：31

作者：

Zou, Mengzhi ^{[1
]}

Wang, Aizhen ^{[2
,3
]}

Wei, Jiajie ^{[4
]}

Cai, Heng ^{[1
]}

Yu, Zixun ^{[1
]}

Zhang, Luyong ^{[1
,5
]}

Wang, Xinzhi ^{[1
]}

机构：

[1] China Pharmaceut Univ, New Drug Screening Ctr, Jiangsu Ctr Pharmacodynam Res & Evaluat, Nanjing 210009, Peoples R China

[2] Xuzhou Med Univ, Affiliated Huaian Hosp, Huaian 223002, Peoples R China

[3] Second Peoples Hosp Huaian, Huaian 223002, Peoples R China

[4] Jiangsu Univ, Dept Nursing, Sch Med, Zhenjiang 212013, Jiangsu, Peoples R China

[5] Guangdong Pharmaceut Univ, Ctr Drug Res & Dev, Guangzhou 510006, Peoples R China

来源：

INTERNATIONAL IMMUNOPHARMACOLOGY | 2021年 / 92卷

基金：

中国国家自然科学基金;

关键词：

Cholestasis; Immune response; Adaptive immune cells; Innate immune cells; Immune regulators; Bile acid; PRIMARY BILIARY-CIRRHOSIS; KILLER T-CELLS; URSODEOXYCHOLIC ACID TREATMENT; PLACEBO-CONTROLLED TRIAL; ANIT-INDUCED CHOLESTASIS; INDUCED LIVER-INJURY; INTRAHEPATIC CHOLESTASIS; BILE-ACIDS; TRANSPORTER EXPRESSION; SIGNALING PATHWAY;

D O I：

10.1016/j.intimp.2020.107328

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

071005 [微生物学]; 100108 [医学免疫学];

摘要：

Cholestasis is one of the most common clinical symptom of liver diseases. If patients do not receive effective treatment, cholestasis can evolve into liver fibrosis, cirrhosis and ultimately liver failure requiring liver transplantation. Currently, only ursodeoxycholic acid, obeticholic acid and bezafibrate are FDA-approved drugs, thereby requiring a breakthrough in new mechanisms and therapeutic development. Inflammation is one of the common complications of cholestasis. Hepatic accumulation of toxic hydrophobic bile acids is a highly immunogenic process involving both resident and immigrating immune cells. And the resulting inflammation may further aggravate hepatocyte injury. Though, great investigations have been made in the immune responses during cholestasis, the relationship between immune responses and cholestasis remains unclear. Moreover, scarce reviews summarize the immune responses during cholestasis and the efficacy of therapies on immune response. The main purpose of this paper is to review the existing literature on dysfunctional immune response during cholestasis and the effect of treatment on immune response which may provide an insight for researchers and drug development.

引用

页数：13

共 135 条

[71]

Role of cell autophagy in the generation of IgM and hepatic fibrosis in primary biliary cholangitis [J].