Preparation of titanated alkoxyallenes from 3-alkoxy-2-propyn-1-yl carbonates and (η2-propene)Ti(O-i-Pr)2 as an efficient ester homoaldol equivalent

被引：24

作者：

Hanazawa, T ^{[1
]}

Okamoto, S ^{[1
]}

Sato, F ^{[1
]}

机构：

[1] Tokyo Inst Technol, Dept Biomol Engn, Midori Ku, Yokohama, Kanagawa 226850, Japan

来源：

ORGANIC LETTERS | 2000年 / 2卷 / 15期

关键词：

D O I：

10.1021/ol006142f

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

[GRAPHICS] 3-Alkoxy-2-propyn-1-yl carbonates (2) react with a divalent titanium reagent (eta(2)-propene)Ti(O-i-Pr)(2) to afford titanated alkoxyallenes 1 which, in turn, react with aldehydes regiospecifically to provide the corresponding gamma-addition products in good to excellent yields, thus affording a convenient method for synthesizing gamma-hydroxy esters 3 and/or gamma-butyrolactones 4.

引用

页码：2369 / 2371

页数：3

共 23 条

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