Diastereoselective synthesis of cyclopentanoids with hydantoin and isoxazoline substituents

被引：29

作者：

Park, KH ^{[1
]}

Olmstead, MM ^{[1
]}

Kurth, MJ ^{[1
]}

机构：

[1] Univ Calif Davis, Dept Chem, Davis, CA 95616 USA

来源：

JOURNAL OF ORGANIC CHEMISTRY | 1998年 / 63卷 / 01期

关键词：

D O I：

10.1021/jo9714831

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Exploiting 1,3-dipolar cycloaddition and urea --> hydantoin cyclization transformations, novel spiro[cyclopenta[d]isoxazole-4',5-imidazoline] heterocycles of generalized structure I have been prepared. The 1-amino-3-cyclopentenecarboxylate precursor II was prepared from a, suitably activated/protected derivative of glycine and the bis-alkylating agent cis-1,4-dichloro-2-butene.

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页码：113 / 117

页数：5

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