Stem-cell niches: nursery rhymes across kingdoms

被引:269
作者
Scheres, Ben [1 ]
机构
[1] Univ Utrecht, Dept Biol, Mol Genet Grp, NL-3584 CH Utrecht, Netherlands
关键词
D O I
10.1038/nrm2164
中图分类号
Q2 [细胞生物学];
学科分类号
071009 ; 090102 ;
摘要
Despite the large evolutionary distance between the plant and animal kingdoms, stem cells in both reside in specialized cellular contexts called stem-cell niches. Although stem-cell-specification factors have been recruited from plant-specific gene families, maintenance factors that repress stem-cell differentiation are conserved between plants and animals. Recent evidence indicates that stem cells in multicellular organisms can be specified by kingdom-specific patterning mechanisms that connect to a related core of epigenetic stem-cell factors.
引用
收藏
页码:345 / 354
页数:10
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