Aurora-kinase inhibitors as anticancer agents

被引：570

作者：

Keen, N ^{[1
]}

Taylor, S

机构：

[1] AstraZeneca, Canc & Infect Res Area, Alderley Pk SK10 4TG, Cheshire, England

[2] Univ Manchester, Fac Life Sci, Manchester M13 9PT, Lancs, England

来源：

NATURE REVIEWS CANCER | 2004年 / 4卷 / 12期

关键词：

D O I：

10.1038/nrc1502

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Errors in mitosis can provide a source of the genomic instability that is typically associated with tumorigenesis. Many mitotic regulators are aberrantly expressed in tumour cells. These proteins could therefore make useful therapeutic targets. The kinases Aurora-A, -B and -C represent a family of such targets and several small-molecule inhibitors have been shown to block their function. Not only have these inhibitors advanced our understanding of mitosis, but, importantly, their in vivo antitumour activity has recently been reported. What have these studies taught us about the therapeutic potential of inhibiting this family of kinases?

引用

页码：927 / 936

页数：10

共 52 条

[1] Essential roles of Drosophila inner centromere protein (INCENP) and aurora B in histone H3 phosphorylation, metaphase chromosome alignment, kinetochore disjunction, and chromosome segregation [J].

Adams, RR ;

Maiato, H ;

Earnshaw, WC ;

Carmena, M .

JOURNAL OF CELL BIOLOGY, 2001, 153 (04) :865-879

[2] Chromosomal passengers and the (aurora) ABCs of mitosis [J].

Adams, RR ;

Carmena, M ;

Earnshaw, WC .

TRENDS IN CELL BIOLOGY, 2001, 11 (02) :49-54

[3] AURORA-A amplification overrides the mitotic spindle assembly checkpoint, inducing resistance to Taxol [J].

Anand, S ;

Penrhyn-Lowe, S ;

Venkitaraman, AR .

CANCER CELL, 2003, 3 (01) :51-62

[4] The budding yeast protein kinase Ipl1/Aurora allows the absence of tension to activate the, spindle checkpoint [J].

Biggins, S ;

Murray, AW .

GENES & DEVELOPMENT, 2001, 15 (23) :3118-3129

[5] A homologue of Drosophila aurora kinase is oncogenic and amplified in human colorectal cancers [J].

Bischoff, JR ;

Anderson, L ;

Zhu, YF ;

Mossie, K ;

Ng, L ;

Souza, B ;

Schryver, B ;

Flanagan, P ;

Clairvoyant, F ;

Ginther, C ;

Chan, CSM ;

Novotny, M ;

Slamon, DJ ;

Plowman, GD .

EMBO JOURNAL, 1998, 17 (11) :3052-3065

[6] The cellular geography of aurora kinases [J].

Carmena, M ;

Earnshaw, WC .

NATURE REVIEWS MOLECULAR CELL BIOLOGY, 2003, 4 (11) :842-854

[7] Survivin is required for stable checkpoint activation in taxol-treated HeLa cells [J].

Carvalho, A ;

Carmena, M ;

Sambade, C ;

Earnshaw, WC ;

Wheatley, SP .

JOURNAL OF CELL SCIENCE, 2003, 116 (14) :2987-2998

[8] TACC1-chTOG-Aurora A protein complex in breast cancer [J].

Conte, N ;

Delaval, B ;

Ginestier, C ;

Ferrand, A ;

Isnardon, D ;

Larroque, C ;

Prigent, C ;

Séraphin, B ;

Jacquemier, J ;

Birnbaum, D .

ONCOGENE, 2003, 22 (50) :8102-8116

[9] Aurora B TACC1 protein complex in cytokinesis [J].

Delaval, B ;

Ferrand, A ;

Conte, N ;

Larroque, C ;

Hernandez-Verdun, D ;

Prigent, C ;

Birnbaum, D .

ONCOGENE, 2004, 23 (26) :4516-4522

[10] Aurora B couples chromosome alignment with anaphase by targeting BubR1, Mad2, and Cenp-E to kinetochores [J].

Ditchfield, C ;

Johnson, VL ;

Tighe, A ;

Ellston, R ;

Haworth, C ;

Johnson, T ;

Mortlock, A ;

Keen, N ;

Taylor, SS .

JOURNAL OF CELL BIOLOGY, 2003, 161 (02) :267-280

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