The chemical reactivity of β-lactams, β-sultams and β-phospholactams

被引：59

作者：

Page, MI ^{[1
]}

Laws, AP ^{[1
]}

机构：

[1] Univ Huddersfield, Dept Chem & Biol Sci, Huddersfield HD1 3DH, W Yorkshire, England

来源：

TETRAHEDRON | 2000年 / 56卷 / 31期

关键词：

beta-lactamase inhibitors; beta-sultams; beta-lactams; beta-phospholactams;

D O I：

10.1016/S0040-4020(00)00412-9

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

beta-Lactam antibiotics display a range of biological activities. The origin of this diverse biological activity is discussed with reference to the chemical reactivity of the small ring system. The reactions of beta-sultams and beta-phospholactams with simple nucleophiles are reported and their potential as mechanism based inhibitors of bacterial and mammalian serine proteases is described. (C) 2000 Elsevier Science Ltd. All rights reserved.

引用

页码：5631 / 5638

页数：8

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