Encoding pheromonal signats in the accessory olfactory bulb of behaving mice

被引:289
作者
Luo, MM [1 ]
Fee, MS
Katz, LC
机构
[1] Duke Univ, Med Ctr, Howard Hughes Med Inst, Durham, NC 27710 USA
[2] Duke Univ, Med Ctr, Dept Neurobiol, Durham, NC 27710 USA
[3] Lucent Technol, Bell Labs, Biol Computat Res Dept, Murray Hill, NJ 07974 USA
关键词
D O I
10.1126/science.1082133
中图分类号
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号
07 ; 0710 ; 09 ;
摘要
Many mammalian species rely on pheromones-semiochemicals produced by other members of the same species-to communicate social status and reproductive readiness. To assess how the central nervous system integrates the complex repertoire of pheromones, we recorded from single neurons in the accessory olfactory bulb, a nucleus that processes pheromonal signals, of mate mice engaged in natural behaviors. Neuronal firing was robustly modulated by physical contact with mate and female conspecifics, with individual neurons activated selectively by specific combinations of the sex and strain of conspecifics. We infer that mammals encode social and reproductive information by integrating vomeronasal sensory activity specific to sex and genetic makeup.
引用
收藏
页码:1196 / 1201
页数:6
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