The effect of non-additive genetic interactions on selection in multi-locus genetic models

被引:29
作者
Hallander, J. [1 ]
Waldmann, P. [1 ]
机构
[1] SLU, UPSC, Dept Forest Genet & Plant Physiol, SE-90183 Umea, Sweden
关键词
dominance; epistasis; heritability; selection response; genetic variation;
D O I
10.1038/sj.hdy.6800946
中图分类号
Q14 [生态学(生物生态学)];
学科分类号
071012 ; 0713 ;
摘要
Additive genetic variance might usually be expected to decrease in a finite population because of genetic drift. However, both theoretical and empirical studies have shown that the additive genetic variance of a population could, in some cases, actually increase owing to the action of genetic drift in presence of non-additive effects. We used Monte-Carlo simulations to address a less-well-studied issue: the effects of directional truncation selection on a trait affected by non-additive genetic variation. We investigated the effects on genetic variance and the response to selection. We compared two different genetic models, representing various numbers of loci. We found that the additive genetic variance could also increase in the case of truncation selection, when dominance and epistasis was present. Additive-by-additive epistatic effects generally gave a higher increase in additive variance compared to dominance. However, the magnitude of the increase differed depending on the particular model and on the number of loci.
引用
收藏
页码:349 / 359
页数:11
相关论文
共 42 条
[1]  
Barton NH, 2004, EVOLUTION, V58, P2111
[2]   Understanding quantitative genetic variation [J].
Barton, NH ;
Keightley, PD .
NATURE REVIEWS GENETICS, 2002, 3 (01) :11-21
[3]  
BRYANT EH, 1986, GENETICS, V114, P1191
[4]   Nonadditive genetic structuring of morphometric variation in relation to a population bottleneck [J].
Bryant, EH ;
Meffert, LM .
HEREDITY, 1996, 77 :168-176
[5]  
Bulmer M. G., 1985, MATH THEORY QUANTITA
[6]   Epistasis and the release of genetic variation during long-term selection [J].
Carlborg, Ö ;
Jacobsson, L ;
Åhgren, P ;
Siegel, P ;
Andersson, L .
NATURE GENETICS, 2006, 38 (04) :418-420
[7]   Epistasis:: too often neglected in complex trait studies? [J].
Carlborg, Ö ;
Haley, CS .
NATURE REVIEWS GENETICS, 2004, 5 (08) :618-U4
[8]   The role of epistatic gene interactions in the response to selection and the evolution of evolvability [J].
Carter, AJR ;
Hermisson, J ;
Hansen, TF .
THEORETICAL POPULATION BIOLOGY, 2005, 68 (03) :179-196
[9]  
Cheverud JM, 1999, EVOLUTION, V53, P1009, DOI [10.2307/2640806, 10.1111/j.1558-5646.1999.tb04516.x]
[10]  
Cheverud JM, 1996, EVOLUTION, V50, P1042, DOI 10.2307/2410645