First synthesis of arylpyrrolo- and pyrazolopyrrolizinones as useful agents with potential biological interest

被引：29

作者：

Rochais, C

Lisowski, V

Dallemagne, P

Rault, S

机构：

[1] UFR Sci Pharmaceut, F-14032 Caen, France

[2] Ctr Etud & Rech Medicament Normandie, F-14032 Caen, France

来源：

TETRAHEDRON LETTERS | 2004年 / 45卷 / 33期

关键词：

cyclisation; pyrroles; pyrazoles; fused-ring systems;

D O I：

10.1016/j.tetlet.2004.06.047

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Novel arylpyrrolo- and pyrazolopyrrolizinones were prepared in three or four steps starting from aminoarylpyrrole and pyrazole carboxylates through the cyclisation of a Vilsmeier-Haack intermediate. This synthesis was enhanced by diverse N-protections of the aza-heterocycle and furnish new series with potential biological interest. (C) 2004 Elsevier Ltd. All rights reserved.

引用

页码：6353 / 6355

页数：3

共 6 条

[1] PREPARATION OF CIS AND TRANS 2,5-DIMETHOXY-2-(ACETAMIDOMETHYL)-2,5-DIHYDROFURAN, OF CISS AND TRANS 2,5-DIMETHOXY-2-(ACETAMIDOMETHYL)-TETRAHYDROFURAN AND OF 1-PHENYL-2-(ACETAMIDOMETHYL)-PYRROLE [J].