The CRF system, stress, depression and anxiety-insights from human genetic studies

被引：273

作者：

Binder, E. B. ^{[1
,2
,3
]}

Nemeroff, C. B. ^{[4
]}

机构：

[1] Max Planck Inst Psychiat, D-80804 Munich, Germany

[2] Emory Univ, Sch Med, Dept Psychiat & Behav Sci, Munich, Germany

[3] Emory Univ, Sch Med, Dept Human Genet, Munich, Germany

[4] Univ Miami, Miller Sch Med, Dept Psychiat & Behav Sci, Miami, FL 33136 USA

来源：

MOLECULAR PSYCHIATRY | 2010年 / 15卷 / 06期

关键词：

CRF; CRH; receptor; genetic; depression; anxiety; CORTICOTROPIN-RELEASING-FACTOR; GENOME-WIDE ASSOCIATION; CEREBROSPINAL-FLUID CONCENTRATIONS; MESSENGER-RNA EXPRESSION; NUCLEOTIDE POLYMORPHISM ANALYSIS; 17Q21.31 MICRODELETION SYNDROME; FACTOR-LIKE IMMUNOREACTIVITY; HEALTHY CONTROL SUBJECTS; HORMONE-BINDING PROTEIN; MAJOR DEPRESSION;

D O I：

10.1038/mp.2009.141

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

A concatenation of findings from preclinical and clinical studies support a preeminent function for the corticotropin-releasing factor (CRF) system in mediating the physiological response to external stressors and in the pathophysiology of anxiety and depression. Recently, human genetic studies have provided considerable support to several long-standing hypotheses of mood and anxiety disorders, including the CRF hypothesis. These data, reviewed in this report, are congruent with the hypothesis that this system is of paramount importance in mediating stress-related psychopathology. More specifically, variants in the gene encoding the CRF1 receptor interact with adverse environmental factors to predict risk for stress-related psychiatric disorders. In-depth characterization of these variants will likely be important in furthering our understanding of the long-term consequences of adverse experience. Molecular Psychiatry (2010) 15, 574-588; doi: 10.1038/mp.2009.141; published online 15 December 2009

引用

页码：574 / 588

页数：15

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