Intravenous levodopa in hallucinating Parkinson's disease patients: High-dose challenge does not precipitate hallucinations

被引:130
作者
Goetz, CG
Pappert, EJ
Blasucci, LM
Stebbins, GT
Ling, ZD
Nora, MV
Carvey, PM
机构
[1] Rush Univ, Rush Presbyterian St Lukes Med Ctr, Dept Neurol Sci, Chicago, IL 60612 USA
[2] Rush Univ, Rush Presbyterian St Lukes Med Ctr, Dept Pharmacol, Chicago, IL 60612 USA
关键词
D O I
10.1212/WNL.50.2.515
中图分类号
R74 [神经病学与精神病学];
学科分类号
摘要
In five nondemented Parkinson's disease patients with daily visual hallucinations, we tested whether high-dose TV levodopa (LD) infusions precipitated hallucinations. Two infusion paradigms were studied, each with 1.5-mg/kg hourly dose for 4 hours-steady infusion and pulse infusion of the full hour dose over 5 minutes each hour. In both protocols, plasma LD levels changed significantly during the infusion protocol. The cumulative area under the curve was equivalent for the two infusions. All patients remained alert, and none developed visual hallucinations. The two patients with peak-dose dyskinesias on oral LD developed prominent dyskinesias during the infusion. Visual hallucinations do not relate simply to high levels of LD or to sudden changes in plasma levels.
引用
收藏
页码:515 / 517
页数:3
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