Role of CD8+ T cells in mycobacterial infections

被引：35

作者：

Smith, SM ^{[1
]}

Dockrell, HM ^{[1
]}

机构：

[1] Univ London London Sch Hyg & Trop Med, Dept Infect & Trop Dis, Immunol Unit, London WC1E 7HT, England

来源：

IMMUNOLOGY AND CELL BIOLOGY | 2000年 / 78卷 / 04期

关键词：

CD8; infection; interferon-gamma; mycobacteria; Mycobacterium tuberculosis; T cell;

D O I：

10.1046/j.1440-1711.2000.00936.x

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

The interaction between IFN-gamma-secreting CD4(+) T cells and macrophages has long been established as integral in the protective immune response against tuberculosis. More recently, evidence from murine experiments and human studies has begun to demonstrate an essential role for MHC class I restricted CD8(+) T cells in this immune response. CD8(+) T cells can produce the protective cytokines IFN-gamma and TNF-alpha in addition to their classical cytolytic functions. However, the exact protective mechanisms and antigens recognized by these important cells remain poorly characterized.

引用

页码：325 / 333

页数：9

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