PtCl2-catalyzed hydrative cyclization of trialkyne functionalities to form bicyclic spiro ketones

被引：55

作者：

Chang, Hsu-Kai ^{[1
]}

Datta, Swarup ^{[1
]}

Das, Arindam ^{[1
]}

Odedra, Arjan ^{[1
]}

Liu, Rai-Shung ^{[1
]}

机构：

[1] Natl Tsing Hua Univ, Dept Chem, Hsinchu 30043, Taiwan

来源：

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2007年 / 46卷 / 25期

关键词：

alkynes; cyclization; homogeneous catalysis; platinum; spiroketones;

D O I：

10.1002/anie.200700022

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

(Chemical Equation Presented) Triple rounds: A regioselective hydrative cyclization of triynes has been developed to give bicyclic β-hydroxy spiro ketones, which undergo subsequent dehydration to give the β,γ- unsaturated ketones (see scheme). Model reactions suggest that this platinum catalysis includes two selective hydrations, an alkyne insertion, and an aldol condensation. © 2007 Wiley-VCH Verlag GmbH & Co. KGaA.

引用

页码：4744 / 4747

页数：4

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