The Origins and Evolution of the p53 Family of Genes

被引：206

作者：

Belyi, Vladimir A. ^{[1
]}

Ak, Prashanth ^{[1
]}

Markert, Elke ^{[1
]}

Wang, Haijian ^{[1
]}

Hu, Wenwei ^{[2
]}

Puzio-Kuter, Anna ^{[2
]}

Levine, Arnold J. ^{[1
,2
]}

机构：

[1] Inst Adv Study, Princeton, NJ 08540 USA

[2] UMDNJ, RWJMS, Canc Inst New Jersey, New Brunswick, NJ 08903 USA

来源：

COLD SPRING HARBOR PERSPECTIVES IN BIOLOGY | 2010年 / 2卷 / 06期

关键词：

TUMOR-SUPPRESSOR GENE; CAENORHABDITIS-ELEGANS P53; KINASE C-ABL; DNA-BINDING; TRANSCRIPTIONAL ACTIVATION; APOPTOTIC RESPONSE; GERMLINE APOPTOSIS; CORE DOMAIN; CELL-DEATH; STEM-CELL;

D O I：

10.1101/cshperspect.a001198

中图分类号：

Q2 [细胞生物学];

学科分类号：

071013 [干细胞生物学];

摘要：

A common ancestor to the three p53 family members of human genes p53, p63, and p73 is first detected in the evolution of modern-day sea anemones, in which both structurally and functionally it acts to protect the germ line from genomic instabilities in response to stresses. This p63/p73 common ancestor gene is found in almost all invertebrates and first duplicates to produce a p53 gene and a p63/p73 ancestor in cartilaginous fish. Bony fish contain all three genes, p53, p63, and p73, and the functions of these three transcription factors diversify in the higher vertebrates. Thus, this gene family has preserved its structural features and functional activities for over one billion years of evolution.

引用

页数：17

共 101 条

[1]

Agami R, 1999, NATURE, V399, P809

[2]

Reduced expression of the Caenorhabditis elegans p53 ortholog cep-1 results in increased longevity [J].