Annulation of ketones with vinamidinium hexafluorophosphate salts: An efficient preparation of trisubstituted pyridines

被引：45

作者：

Marcoux, JF ^{[1
]}

Corley, EG ^{[1
]}

Rossen, K ^{[1
]}

Pye, P ^{[1
]}

Wu, J ^{[1
]}

Robbins, MA ^{[1
]}

Davies, IW ^{[1
]}

Larsen, RD ^{[1
]}

Reider, PJ ^{[1
]}

机构：

[1] Merck & Co Inc, Dept Proc Res, Rahway, NJ 07065 USA

来源：

ORGANIC LETTERS | 2000年 / 2卷 / 15期

关键词：

D O I：

10.1021/ol006097b

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

[GRAPHICS] alpha-Aryl ketones react with vinamidinium hexafluorophosphate salts to give access to the corresponding 3-arylpyridines, The annulation reactions proceed in good to excellent yields with vinamidinium salts containing electron-withdrawing groups at the beta-position (R-2). The reaction was applied to the preparation of the COX-2 specific inhibitor 5-chloro-3-(4-methylsulfonyl)phenyl-2-(2-methyl-5-pyridynl)pyridine (1), as well as a series of analogues.

引用

页码：2339 / 2341

页数：3

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