Issues surrounding standard cytotoxicity testing for assessing activity of non-covalent DNA-binding metallo-drugs

被引：26

作者：

Pope, Alexandra. J. ^{[1
]}

Bruce, Christopher ^{[2
]}

Kysela, Boris ^{[2
]}

Hannon, Michael. J. ^{[1
]}

机构：

[1] Univ Birmingham, Sch Chem, Birmingham B91 2ES, W Midlands, England

[2] Univ Birmingham, Sch Clin & Expt Med, Coll Med & Dent Sci, Sect Med & Mol Genet, Birmingham B15 2TT, W Midlands, England

来源：

DALTON TRANSACTIONS | 2010年 / 39卷 / 11期

关键词：

MOLECULAR RECOGNITION; PLATINUM; CANCER; OSTEOSARCOMA; CHEMOTHERAPY; GENOTOXICITY; CISPLATIN; LEUKEMIA; HELICATE; JUNCTION;

D O I：

10.1039/b927129p

中图分类号：

O61 [无机化学];

学科分类号：

070301 ; 081704 ;

摘要：

Investigating the methods commonly used to evaluate in vitro cytotoxicity of novel compounds, specifically non-covalent DNA binders, identifies that these methods may not be appropriate. The level of anticancer activity depends not only on the incubation time but also on the absolute amount (number of moles) of drug compound applied, rather than the concentration.

引用

页码：2772 / 2774

页数：3

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