Human diversity in killer cell inhibitory receptor genes

被引：918

作者：

Uhrberg, M

Valiante, NM

Shum, BP

Shilling, HG

Lienert-Weidenbach, K

Corliss, B

Tyan, D

Lanier, LL

Parham, P ^{[1
]}

机构：

[1] Stanford Univ, Sch Med, Dept Biol Struct, Stanford, CA 94305 USA

[2] Stanford Univ, Sch Med, Dept Immunol & Microbiol, Stanford, CA 94305 USA

[3] DNAX Res Inst Mol & Cellular Biol Inc, Dept Immunobiol, Palo Alto, CA 94306 USA

[4] Univ Calif Los Angeles, Cedars Sinai Med Ctr, Sch Med, Steven Spielberg Pediat Res Ctr, Los Angeles, CA 90048 USA

[5] Univ Calif Los Angeles, Cedars Sinai Med Ctr, Sch Med, Dept Pediat, Los Angeles, CA 90048 USA

来源：

IMMUNITY | 1997年 / 7卷 / 06期

关键词：

D O I：

10.1016/S1074-7613(00)80394-5

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

The presence and expression of killer inhibitory receptor (KIR) and CD94:NKG2 genes from 68 donors were analyzed using molecular typing techniques. The genes encoding CD94:NKG2 receptors were present in each person, but KIR gene possession varied. Most individuals expressed inhibitory KIR for the three well-defined HLA-B and -C ligands, but noninhibitory KIR genes were more variable. Twenty different KIR phenotypes were defined. Two groups of KIR haplotypes were distinguished and occurred at relatively even frequency. Group A KIR haplotypes consist of six genes: the main inhibitory KIR, one noninhibitory KIR, and a structurally divergent KIR. Allelic polymorphism within five KIR genes was detected. Group B comprises more noninhibitory KIR genes and contains at least one additional gene not represented in group A. The KIR locus therefore appears to be polygenic and polymorphic within the human population.

引用

页码：753 / 763

页数：11

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