Fiber assembly by the chaperone-usher pathway

被引：156

作者：

Sauer, FG

Remaut, H

Hultgren, SJ

Waksman, G

机构：

[1] Washington Univ, Sch Med, Dept Mol Microbiol, St Louis, MO 63110 USA

[2] Yale Univ, Sch Med, Sect Microbial Pathogenesis, Boyer Ctr Mol Med, New Haven, CT 06536 USA

[3] Univ London Birkbeck Coll, Inst Struct Mol Biol, Sch Crystallog, London WC1E 7HX, England

[4] UCL, Dept Biochem & Mol Biol, London WC1E 6BT, England

来源：

BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH | 2004年 / 1694卷 / 1-3期

关键词：

structural basis of fiber formation; pilus assembly; chaperone-usher pathway; bacterial pathogenesis; protein folding;

D O I：

10.1016/j.bbamcr.2004.02.010

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Bacterial pathogens utilize the chaperone-usher pathway to assemble extracellular multi-subunit fibers essential for virulence. The periplasmic chaperone facilitates the initial folding of fiber subunits but then traps them in activated folding transition states. Chaperone dissociation releases the folding energy that drives subunit incorporation into the fiber. which grows through a pore formed by the outermembrane usher. (C) 2004 Elsevier B.V. All rights reserved.

引用

收藏

页码：259 / 267

页数：9

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