Sphingosine-1-phosphate: An enigmatic signalling lipid

被引：1744

作者：

Spiegel, S

Milstien, S

机构：

[1] Virginia Commonwealth Univ, Dept Biochem, Richmond, VA 23298 USA

[2] NIMH, Lab Cellular & Mol Regulat, Bethesda, MD 20892 USA

来源：

NATURE REVIEWS MOLECULAR CELL BIOLOGY | 2003年 / 4卷 / 05期

基金：

美国国家卫生研究院;

关键词：

D O I：

10.1038/nrm1103

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

The evolutionarily conserved actions of the sphingolipid metabolite, sphingosine-1-phosphate (S1P), in yeast, plants and mammals have shown that it has important functions. In higher eukaryotes, S1P is the ligand for a family of five G-protein-coupled receptors. These S1P receptors are differentially expressed, coupled to various G proteins, and regulate angiogenesis, vascular maturation, cardiac development and immunity, and are important for directed cell movement.

引用

页码：397 / 407

页数：11

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