Sphingosine-1-phosphate: An enigmatic signalling lipid

被引：1744

作者：

Spiegel, S

Milstien, S

机构：

[1] Virginia Commonwealth Univ, Dept Biochem, Richmond, VA 23298 USA

[2] NIMH, Lab Cellular & Mol Regulat, Bethesda, MD 20892 USA

来源：

NATURE REVIEWS MOLECULAR CELL BIOLOGY | 2003年 / 4卷 / 05期

基金：

美国国家卫生研究院;

关键词：

D O I：

10.1038/nrm1103

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

The evolutionarily conserved actions of the sphingolipid metabolite, sphingosine-1-phosphate (S1P), in yeast, plants and mammals have shown that it has important functions. In higher eukaryotes, S1P is the ligand for a family of five G-protein-coupled receptors. These S1P receptors are differentially expressed, coupled to various G proteins, and regulate angiogenesis, vascular maturation, cardiac development and immunity, and are important for directed cell movement.

引用

页码：397 / 407

页数：11

共 91 条

[81] Thudichum J. L. W., 1884, TREATISE CHEM CONSTI, P149
[82] Sphingosine kinase-mediated calcium signaling by muscarinic acetylcholine receptors
van Koppen, CJ
Heringdork, DMZ
Alemany, R
Jakobs, KH
[J]. LIFE SCIENCES, 2001, 68 (22-23) : 2535 - 2540
[83] Sphingolipid transport in eukaryotic cells
van Meer, G
Holthuis, JCM
[J]. BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS, 2000, 1486 (01): : 145 - 170
[84] Human sphingosine-1-phosphate lyase: cDNA cloning, functional expression studies and mapping to chromosome 10q22
Van Veldhoven, PP
Gijsbers, S
Mannaerts, GP
Vermeesch, JR
Brys, V
[J]. BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS, 2000, 1487 (2-3): : 128 - 134
[85] cis-4-Methylsphingosine decreases sphingolipid biosynthesis by specifically interfering with serine palmitoyltransferase activity in primary cultured neurons
vanEchtenDeckert, G
Zschoche, A
Bar, T
Schmidt, RR
Raths, A
Heinemann, T
Sandhoff, K
[J]. JOURNAL OF BIOLOGICAL CHEMISTRY, 1997, 272 (25) : 15825 - 15833
[86] Sphingosine 1-phosphate stimulates cell migration through a Gi-coupled cell surface receptor -: Potential involvement in angiogenesis
Wang, F
Van Brocklyn, JR
Hobson, JP
Movafagh, S
Zukowska-Grojec, Z
Milstien, S
Spiegel, S
[J]. JOURNAL OF BIOLOGICAL CHEMISTRY, 1999, 274 (50) : 35343 - 35350
[87] An oncogenic role of sphingosine kinase
Xia, P
Gamble, JR
Wang, LJ
Pitson, SM
Moretti, PAB
Wattenberg, BW
D'Andrea, RJ
Vadas, MA
[J]. CURRENT BIOLOGY, 2000, 10 (23) : 1527 - 1530
[88] Sphingosine kinase interacts with TRAF2 and dissects tumor necrosis factor-α signaling
Xia, P
Wang, LJ
Moretti, PAB
Albanese, N
Chai, FG
Pitson, SM
D'Andrea, RJ
Gamble, JR
Vadas, MA
[J]. JOURNAL OF BIOLOGICAL CHEMISTRY, 2002, 277 (10) : 7996 - 8003
[89] Sphingoid base synthesis requirement for endocytosis in Saccharomyces cerevisiae
Zanolari, B
Friant, S
Funato, K
Sütterlin, C
Stevenson, BJ
Riezman, H
[J]. EMBO JOURNAL, 2000, 19 (12) : 2824 - 2833
[90] SPHINGOSINE-1-PHOSPHATE, A NOVEL LIPID, INVOLVED IN CELLULAR PROLIFERATION
ZHANG, H
DESAI, NN
OLIVERA, A
SEKI, T
BROOKER, G
SPIEGEL, S
[J]. JOURNAL OF CELL BIOLOGY, 1991, 114 (01) : 155 - 167

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