Ionic substitutions in calcium phosphates synthesized at low temperature

被引:671
作者
Boanini, E. [1 ]
Gazzano, M. [2 ]
Bigi, A. [1 ]
机构
[1] Univ Bologna, Dept Chem G Ciamician, I-40126 Bologna, Italy
[2] ISOF CNR, Dept Chem G Ciamician, Bologna, Italy
关键词
Calcium phosphates; Ionic substitutions; Hydroxyapatite; Bone cements; Biomimetic coatings; BETA-TRICALCIUM PHOSPHATE; HUMAN OSTEOBLAST RESPONSE; IN-VITRO BIOACTIVITY; OCTACALCIUM PHOSPHATE; BONE-FORMATION; PHYSICOCHEMICAL PROPERTIES; DOPED HYDROXYAPATITE; SYNTHETIC APATITES; SURFACE ENRICHMENT; SETTING PROPERTIES;
D O I
10.1016/j.actbio.2009.12.041
中图分类号
R318 [生物医学工程];
学科分类号
100103 [病原生物学];
摘要
Ionic substitutions have been proposed as a tool to improve the biological performance of calcium phosphate based materials. This review provides an overview of the recent results achieved on ion-substituted calcium phosphates prepared at low temperature, i.e. by direct synthesis in aqueous medium or through hydrolysis of more soluble calcium phosphates. Particular attention is focused on several ions, including Si, Sr, Mg, Zn and Mn, which are attracting increasing interest for their possible biological role, and on the recent trends and developments in the applications of ion-substituted calcium phosphates in the biomedical field. (C) 2009 Acta Materialia Inc. Published by Elsevier Ltd. All rights reserved.
引用
收藏
页码:1882 / 1894
页数:13
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