Cationic Vesicles Based on Amphiphilic Pillar[5]arene Capped with Ferrocenium: A Redox-Responsive System for Drug/siRNA Co-Delivery

被引：328

作者：

Chang, Yincheng ^{[1
]}

Yang, Kui ^{[1
]}

Wei, Peng ^{[1
]}

Huang, Sisi ^{[1
]}

Pei, Yuxin ^{[1
]}

Zhao, Wei ^{[1
]}

Pei, Zhichao ^{[1
]}

机构：

[1] Northwest A&F Univ, Coll Sci, Yangling 712100, Shaanxi, Peoples R China

来源：

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2014年 / 53卷 / 48期

基金：

中国国家自然科学基金;

关键词：

cationic vesicles; drug/siRNA co-delivery; nanostructures; redox-responsive system; self-assembly; MESOPOROUS SILICA NANOPARTICLES; LIPID-LIKE NANOPARTICLES; SMALL INTERFERING RNA; IN-VITRO; DRUG-RESISTANCE; ANTICANCER DRUG; CANCER; RELEASE; WATER; SIRNA;

D O I：

10.1002/anie.201407272

中图分类号：

O6 [化学];

学科分类号：

070301 [无机化学];

摘要：

A novel ferrocenium capped amphiphilic pillar[5]arene (FCAP) was synthesized and self-assembled to cationic vesicles in aqueous solution. The cationic vesicles, displaying low cytotoxicity and significant redox-responsive behavior due to the redox equilibrium between ferrocenium cations and ferrocenyl groups, allow building an ideal glutathione (GSH)-responsive drug/siRNA co-delivery system for rapid drug release and gene transfection in cancer cells in which higher GSH concentration exists. This is the first report of redox-responsive vesicles assembled from pillararenes for drug/siRNA co-delivery; besides enhancing the bioavailability of drugs for cancer cells and reducing the adverse side effects for normal cells, these systems can also overcome the drug resistance of cancer cells. This work presents a good example of rational design for an effective stimuli-responsive drug/siRNA co-delivery system.

引用

页码：13126 / 13130

页数：5

共 45 条

[1]

Lipid-Peptide Vesicle Nanoscale Hybrids for Triggered Drug Release by Mild Hyperthermia in Vitro and in Vivo [J].