Dynamic regulation of leptin entry into brain by the blood-brain barrier

被引：83

作者：

Kastin, AJ

Pan, WH

机构：

[1] Vet Adm Med Ctr, New Orleans, LA 70112 USA

[2] Tulane Univ, Sch Med, New Orleans, LA 70112 USA

来源：

REGULATORY PEPTIDES | 2000年 / 92卷 / 1-3期

关键词：

transporter; satiety; fasting; obesity;

D O I：

10.1016/S0167-0115(00)00147-6

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Regulation of the transport of leptin across the blood-brain barrier (BBB) may be crucial for its effects on food ingestion and obesity and may be responsible for 'leptin resistance'. This review summarizes current studies of leptin indicating a dynamic role of the BBB. It includes evidence for its susceptibility to change by physiological stimuli such as starvation, refeeding, and time of day. Although the short form of the leptin receptor is involved in leptin transport, it appears that other mechanisms of entry also exist. Regardless, the BBB is intimately involved with the regulation of the actions of leptin. (C) 2000 Published by Elsevier Science B.V.

引用

页码：37 / 43

页数：7

共 53 条

[21] Physiological response to long-term peripheral and central leptin infusion in lean and obese mice [J].

Halaas, JL ;

Boozer, C ;

BlairWest, J ;

Fidahusein, N ;

Denton, DA ;

Friedman, JM .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1997, 94 (16) :8878-8883

[22] Peptides crossing the blood-brain barrier: some unusual observations [J].

Kastin, AJ ;

Pan, WH ;

Maness, LM ;

Banks, WA .

BRAIN RESEARCH, 1999, 848 (1-2) :96-100

[23] Entry of CART into brain is rapid but not inhibited by excess CART or leptin [J].

Kastin, AJ ;

Akerstrom, V .

AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM, 1999, 277 (05) :E901-E904

[24] Nonsaturable entry of neuropeptide Y into brain [J].

Kastin, AJ ;

Akerstrom, V .

AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM, 1999, 276 (03) :E479-E482

[25] Fasting, but not adrenalectomy, reduces transport of leptin into the brain [J].

Kastin, AJ ;

Akerstrom, V .

PEPTIDES, 2000, 21 (05) :679-682

[26]

Kastin AJ, 1999, J PHARMACOL EXP THER, V289, P219

[27] Decreased transport of leptin across the blood-brain barrier in rats lacking the short form of the leptin receptor [J].

Kastin, AJ ;

Pan, WH ;

Maness, LM ;

Koletsky, RJ ;

Ernsberger, P .

PEPTIDES, 1999, 20 (12) :1449-1453

[28] Phe13,Tyr19-melanin-concentrating hormone and the blood-brain barrier:: Role of protein binding [J].

Kastin, AJ ;

Akerstrom, V ;

Hackler, L ;

Zadina, JE .

JOURNAL OF NEUROCHEMISTRY, 2000, 74 (01) :385-391

[29]

KASTIN AJ, 2000, IN PRESS METABOLISM

[30]

Koistinen HA, 1998, EUR J CLIN INVEST, V28, P894

← 1 2 3 4 5 6 →