Definitions of enzyme function for the structural genomics era

被引：52

作者：

Babbitt, PC

机构：

[1] Univ Calif San Francisco, Dept Biopharmaceut Sci, San Francisco, CA 94143 USA

[2] Univ Calif San Francisco, Dept Pharmaceut Chem, San Francisco, CA 94143 USA

来源：

CURRENT OPINION IN CHEMICAL BIOLOGY | 2003年 / 7卷 / 02期

关键词：

D O I：

10.1016/S1367-5931(03)00028-0

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Questions are being asked about how enzyme function is described at the molecular level and the strengths and weaknesses of the EC system for this purpose. A new approach to describing enzyme function has been proposed that might improve our capabilities for functional inference for members of enzyme superfamilies.

引用

页码：230 / 237

页数：8

共 58 条

[1] Evolution of enzymes in metabolism: A network perspective
Alves, R
Chaleil, RAG
Sternberg, MJE
[J]. JOURNAL OF MOLECULAR BIOLOGY, 2002, 320 (04) : 751 - 770
[2] [Anonymous], 1992, ENZYME NOMENCLATURE
[3] Mechanistic diversity in a metalloenzyme superfamily
Armstrong, RN
[J]. BIOCHEMISTRY, 2000, 39 (45) : 13625 - 13632
[4] A GRAPH-THEORETIC APPROACH TO THE IDENTIFICATION OF 3-DIMENSIONAL PATTERNS OF AMINO-ACID SIDE-CHAINS IN PROTEIN STRUCTURES
ARTYMIUK, PJ
POIRRETTE, AR
GRINDLEY, HM
RICE, DW
WILLETT, P
[J]. JOURNAL OF MOLECULAR BIOLOGY, 1994, 243 (02) : 327 - 344
[5] Ashburner M, 2001, GENOME RES, V11, P1425
[6] The structure of 3-methylaspartase from Clostridium tetanomorphum functions via the common enolase chemical step
Asuncion, M
Blankenfeldt, W
Barlow, JN
Gani, D
Naismith, JH
[J]. JOURNAL OF BIOLOGICAL CHEMISTRY, 2002, 277 (10) : 8306 - 8311
[7] Babbitt PC, 2001, ADV PROTEIN CHEM, V55, P1, DOI 10.1016/S0065-3233(01)55001-9
[8] The enolase superfamily: A general strategy for enzyme-catalyzed abstraction of the alpha-protons of carboxylic acids
Babbitt, PC
Hasson, MS
Wedekind, JE
Palmer, DRJ
Barrett, WC
Reed, GH
Rayment, I
Ringe, D
Kenyon, GL
Gerlt, JA
[J]. BIOCHEMISTRY, 1996, 35 (51) : 16489 - 16501
[9] Understanding enzyme superfamilies - Chemistry as the fundamental determinant in the evolution of new catalytic activities
Babbitt, PC
Gerlt, JA
[J]. JOURNAL OF BIOLOGICAL CHEMISTRY, 1997, 272 (49) : 30591 - 30594
[10] Insights into the mechanism of catalysis by the P-C bond-cleaving enzyme phosphonoacetaldehyde hydrolase derived from gene sequence analysis and mutagenesis
Baker, AS
Ciocci, MJ
Metcalf, WW
Kim, J
Babbitt, PC
Wanner, BL
Martin, BM
Dunaway-Mariano, D
[J]. BIOCHEMISTRY, 1998, 37 (26) : 9305 - 9315

← 1 2 3 4 5 6 →