Subtilisin-related serine proteases in the mammalian constitutive secretory pathway

被引：28

作者：

Gensberg, K ^{[1
]}

Jan, S ^{[1
]}

Matthews, GM ^{[1
]}

机构：

[1] Queen Elizabeth Hosp, Dept Surg, Birmingham B15 2TH, W Midlands, England

来源：

SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY | 1998年 / 9卷 / 01期

关键词：

furin; PACE4; PC4; PC5,6; LPC;

D O I：

10.1006/scdb.1997.0196

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Proteolytic cleavage is a hey step in the activation of many secreted proteins. Since the identification of the prototype yeast enzyme Kex2, seven subtilisin-related serine proteases, together with a number of isoforms, have been identified in mammalian cells, Jive of which act within the constitutive secretory pathway. Overlapping expression patterns and substrate specificities complicate analysis but individual roles are beginning to emerge for some members of the group.

引用

页码：11 / 17

页数：7

共 70 条

[61] TAKAHASHI S, 1995, J BIOL CHEM, V270, P28397
[62] THE TISSUE DISTRIBUTION OF MESSENGER-RNAS FOR THE PACE4 ISOFORMS, KEXIN-LIKE PROCESSING PROTEASE - PACE4C AND PACE4D MESSENGER-RNAS ARE MAJOR TRANSCRIPTS AMONG PACE4 ISOFORMS
TSUJI, A
MORI, K
HINE, C
TAMAI, Y
NAGAMUNE, H
MATSUDA, Y
[J]. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 1994, 202 (03) : 1215 - 1221
[63] IDENTIFICATION OF NOVEL CDNAS ENCODING HUMAN KEXIN-LIKE PROTEASE, PACE4 ISOFORMS
TSUJI, A
HIGASHINE, K
HINE, C
MORI, K
TAMAI, Y
NAGAMUNE, H
MATSUDA, Y
[J]. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 1994, 200 (02) : 943 - 950
[64] TSUNEOKA M, 1993, J BIOL CHEM, V268, P26461
[65] Biosynthesis, distinct post-translational modifications, and functional characterization of lymphoma proprotein convertase
vandeLoo, JWHP
Creemers, JWM
Bright, NA
Young, BD
Roebroek, AJM
VandeVen, WJM
[J]. JOURNAL OF BIOLOGICAL CHEMISTRY, 1997, 272 (43) : 27116 - 27123
[66] STRUCTURAL HOMOLOGY BETWEEN THE HUMAN FUR GENE-PRODUCT AND THE SUBTILISIN-LIKE PROTEASE ENCODED BY YEAST KEX2
VANDENOUWELAND, AMW
VANDUIJNHOVEN, HLP
KEIZER, GD
DORSSERS, LCJ
VANDEVEN, WJM
[J]. NUCLEIC ACIDS RESEARCH, 1990, 18 (03) : 664 - 664
[67] MATURATION OF THE TRANS-GOLGI NETWORK PROTEASE FURIN - COMPARTMENTALIZATION OF PROPEPTIDE REMOVAL, SUBSTRATE CLEAVAGE, AND COOH-TERMINAL TRUNCATION
VEY, M
SCHAFER, W
BERGHOFER, S
KLENK, HD
GARTEN, W
[J]. JOURNAL OF CELL BIOLOGY, 1994, 127 (06) : 1829 - 1842
[68] CHARACTERIZATION OF A SECRETED FORM OF HUMAN FURIN ENDOPROTEASE
VIDRICAIRE, G
DENAULT, JB
LEDUC, R
[J]. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 1993, 195 (02) : 1011 - 1018
[69] Comparative cellular processing of the human immunodeficiency virus (HIV-1) envelope glycoprotein gp160 by the mammalian subtilisin/kexin-like convertases
Vollenweider, F
Benjannet, S
Decroly, E
Savaria, D
Lazure, C
Thomas, G
Chretien, M
Seidah, NG
[J]. BIOCHEMICAL JOURNAL, 1996, 314 : 521 - 532
[70] Functional analysis of human PACE4-A and PACE4-C isoforms: Identification of a new PACE4-CS isoform
Zhong, M
Benjannet, S
Lazure, C
Munzer, S
Seidah, NG
[J]. FEBS LETTERS, 1996, 396 (01) : 31 - 36

← 1 2 3 4 5 6 7 →